Synthetic Marijuana Effect on Psychosis

Faculty Sponsor

Jana Stedman

College

College of Nursing & Health Professions (CONHP)

Department/Program

Physicians Assistant Masters Program

Presentation Type

Poster Presentation

Symposium Date

Summer 7-23-2025

Abstract

This study explores the relationship between synthetic marijuana (commonly known as K2 or Spice) use and the onset of psychotic symptoms in individuals without a prior history of mental illness. The research aims to assess whether synthetic cannabinoids contribute to schizophrenia-like symptoms, with particular focus on the short-term psychological effects. A literature review was conducted using Google Scholar to identify peer-reviewed studies examining psychosis induced by synthetic cannabinoids, specifically K2/Spice. Search terms included: “Spice/K2” (545 results), “Spice psychosis” (2,770), “Pure cannabis psychosis” (7,750), “Irreversible psychosis spice induced” (506), and “Schizophrenia K2/Spice” (87). Articles were manually screened for relevance based on titles and abstracts. Inclusion criteria required studies to involve participants who used only K2/Spice, had no prior mental health diagnosis, and were published in English. Studies were excluded if participants used other substances, were outside the target age range, or had pre-existing psychiatric conditions. The primary outcomes of interest included psychotic symptoms such as delusions, rapid or pressured speech, and increased aggression. Symptom severity was compared before and after K2/Spice use using clinical reports and behavioral assessments. Findings across multiple studies consistently indicated that use of synthetic marijuana can induce acute psychotic symptoms in previously healthy individuals. Reported effects included hallucinations, paranoia, aggression, and disorganized speech. Some users experienced symptoms severe enough to require hospitalization. Although many symptoms were transient, there is insufficient evidence to determine long-term psychological outcomes, and the potential for irreversible effects remains unclear. The use of synthetic cannabinoids such as K2/Spice poses significant mental health risks, particularly in inducing psychosis in users without prior psychiatric conditions. Continued research is necessary to clarify the long-term effects and develop appropriate public health responses.

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