College

College of Nursing & Health Professions (CONHP)

Department/Program

PA

Presentation Type

Poster Presentation

Symposium Date

Summer 7-23-2025

Abstract

This research aims to determine whether intermittent (luteal phase) or continuous selective serotonin reuptake inhibitor (SSRI) dosing is more effective in reducing symptoms of premenstrual dysphoric disorder (PMDD). A structured literature review was conducted using Google Scholar, PubMed, and the Christopher Center Library database. Search terms included “PMDD,” “premenstrual dysphoric disorder,” “SSRIs,” “continuous dosing,” “intermittent dosing,” and “luteal phase.” Inclusion criteria were English-language studies involving adult women with full-text availability and examining continuous and/or intermittent SSRI use. Exclusion criteria included non-English publications, unavailable full texts, and pediatric populations.

Sixteen sources were selected: five empirical studies (randomized controlled trials and observational studies) and eleven clinical guidelines or supplemental overviews. Due to heterogeneity in study design and outcome measures, a narrative synthesis was used to compare treatment efficacy and clinical considerations.

SSRIs are effective in reducing emotional symptoms of PMDD, but no consensus exists regarding the optimal dosing regimen. One review suggested continuous dosing may be more effective than luteal-phase dosing, while other studies found no significant difference between the two approaches. Given small sample sizes and limited data, conclusions remain tentative.

Both dosing strategies appear beneficial. Treatment decisions should be based on shared decision-making, considering factors such as menstrual cycle regularity, medication adherence, and withdrawal risk. In the absence of a clear clinical indication or patient preference, continuous dosing may be preferred due to preliminary evidence suggesting greater efficacy and its relative simplicity. Overall, SSRI dosing for PMDD should be personalized to optimize outcomes.

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