Faculty Sponsor

Jana Stedman

College

College of Nursing & Health Professions (CONHP)

Department/Program

MSPA

ORCID Identifier(s)

https://orcid.org/0009-0001-4222-610X

Presentation Type

Poster Presentation

Symposium Date

Summer 7-23-2025

Abstract

Objective: This project aims to investigate the relationship between estrogen and progesterone levels in postmenopausal women with carpal tunnel syndrome (CTS), and to evaluate the potential effects of hormone replacement therapy (HRT) on this population.

Methods: A structured literature review was conducted using Medline via EBSCO and PubMed databases to identify studies published between 2013 and 2024. Keywords included “carpal tunnel syndrome,” “hormone replacement therapy,” and “estrogen.” The Medline search yielded 8 relevant articles, while PubMed returned 9 studies for “carpal tunnel syndrome and estrogen” and 5 for “carpal tunnel syndrome and hormone replacement therapy.” Inclusion criteria focused on studies involving postmenopausal women diagnosed with CTS, excluding premenopausal populations. The primary outcomes examined were the correlation between hormone levels and CTS incidence, and the therapeutic impact of HRT in postmenopausal women.

Results: Findings suggest a possible link between decreased estrogen levels and increased CTS incidence in postmenopausal women. Several studies indicate that HRT may reduce the risk of CTS in this population, likely due to hormonal regulation. However, one study reported a potential increased risk of CTS associated with HRT use, highlighting conflicting evidence in current literature.

Conclusion: While current evidence suggests a possible protective role of HRT against CTS in postmenopausal women, the findings are not conclusive. Given the variation in reported outcomes, clinicians should carefully consider individual patient factors, weighing both potential benefits and risks of HRT as a preventive or therapeutic option for CTS.

Keywords: carpal tunnel syndrome, postmenopausal women, hormone replacement therapy, estrogen, progesterone, women’s health

Biographical Information about Author(s)

Ameena Madani has a special interest in Internal Medicine and plans on working in Illinois following graduation. She will be presenting on “Hormone Therapy and Carpal Tunnel in Postmenopausal Women” because she has a special interest in treatment and care of postmenopausal women.

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