Faculty Sponsor

Jana Stedman

College

Nursing

Department/Program

Physician Assistant Program

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Objective: To compare efficacy rates of metformin as monotherapy versus clomiphene, an ovulation inducer, in increasing pregnancy rates among women with polycystic ovary syndrome (PCOS).

Methods: Multiple databases were explored to compile a list of potential sources to answer the main study question. Multiple search terms and various combinations of the terms were used including PCOS, polycystic ovary syndrome, Clomid, Metformin, pregnancy, and ovulation. After applying inclusion criteria and exclusion criteria, five sources were selected. Two meta-analyses, two randomized control trials, and one prospective cross-sectional study were selected. Primary endpoints included live birth rates and clinical pregnancy rates. Results from each study were compared to decide if metformin as monotherapy was as effective as clomiphene in increasing pregnancy rates in women with PCOS.

Results: Metformin as monotherapy does improve pregnancy rates more than no medical treatment. However, combined therapy of metformin plus clomiphene provided the most statistically significant increase in live birth rates and clinical pregnancy rates.

Conclusion: Combination therapy, metformin plus clomiphene citrate, proves to be the most effective treatment option to increase rates of pregnancy as well as live birth rate among women with PCOS who are infertile. However, monotherapy of either is better than no treatment at all.

Keywords: polycystic ovary syndrome, metformin, clomiphene, ovulation, pregnancy, infertility, live birth rate, hormones, comorbidities

Biographical Information about Author(s)

Shannon Shipman is interested in Women’s Health, Emergency Medicine, and General Surgery and plans on working in one of those specialties after graduation back home in Chicago, IL. Shannon has a special interest in Polycystic Ovary Syndrome ever since she was diagnosed with PCOS at a young age and has wanted to learn more about how it affects her body as well as her future patients’.

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