IV Ketamine and Treatment Resistant Depression
Faculty Sponsor
Jana Stedman
College
Nursing
Department/Program
Physician Assistant Program
Presentation Type
Poster Presentation
Symposium Date
Summer 7-24-2024
Abstract
Objective: Treatment resistant depression (TRD) affects many individuals diagnosed with major depressive disorder (MDD). This paper aims to compare the efficacy of ketamine in comparison to previously established treatment options such as transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). Methods: Recent literature was used to conduct a systematic review and compare ketamine, ECT, and TMS, in the management of TRD. Studies within the last five years were included and made use of both randomized control trials and retrospective cohort studies. Primary endpoints were measured using depression rating scales such as HAMD, MADRS, CGI, QIDS, and BDI. Results: Ketamine demonstrated effectiveness in achieving remission in some cases and reducing overall depressive symptoms. Although more acute side effects were noted with ketamine, long-term adverse events were fewer than that of ECT and TMS. Conclusion: Ketamine demonstrates promise as a treatment option for TRD. Further research is indicated to determine optimal dosing and methods of administration to favor improved patient outcomes
Keywords: treatment resistant depression, ketamine, electroconvulsive therapy, transcranial magnetic stimulation, remission, TRD, ECT, TMS, esketamine
Recommended Citation
Yeager, Rachel, "IV Ketamine and Treatment Resistant Depression" (2024). Summer Interdisciplinary Research Symposium. 219.
https://scholar.valpo.edu/sires/219
Biographical Information about Author(s)
Rachel Yeager has a special interest in surgery and plans to pursue a surgical specialty after graduation. To gain additional surgical experience following graduation, she also plans to participate in a medical mission’s trip to Kenya. Rachel will be presenting on “Ketamine in the management of Treatment Resistant Depression,” a topic that sparked her interest during a psychiatry rotation where she observed significant patient benefits from ketamine treatments.