Faculty Sponsor

Jana Stedman

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College

Nursing

Department/Program

Physcian Assistant Program

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Objectives: This paper compares effectiveness of clomiphene citrate and letrozole in treating anovulation in women experiencing anovulatory infertility due to polycystic ovarian syndrome (PCOS). Included are secondary comparisons effectiveness between letrozole and clomiphene citrate on rates of pregnancy and risks of multiple pregnancies.

Methods: Google scholar, PubMed, and Cochrane Library were the websites used. The date of articles published was set from 2019 to the present. Exclusion criteria included any other form of infertility that was not contributed to PCOS, articles not written in English, articles without full text available, and studies investigating fertility treatments other than clomiphene citrate and letrozole. A total of five studies were analyzed.

Results: Studies selected compared the rates of ovulation between two groups of women. One group was treated with letrozole and the other with clomiphene citrate. Population ranged from 28 to 200 participants. Letrozole was proven to have higher ovulation rates than in the groups that were given clomiphene citrate. Results were measured by number of women who ovulated. Secondary endpoints were recorded.

Conclusion: Letrozole was found to be more effective at increasing rates of ovulation in women with infertility due to anovulatory PCOS than clomiphene citrate. Secondary endpoints showed that the use of letrozole had higher probability of successful pregnancy and live birth, whereas clomiphene citrate had higher probability of spontaneous abortion. Letrozole was more probable to result in single gestation where clomiphene citrate showed higher potential of multiple gestation.

Keywords: clomiphene citrate, clomid, letrozole, infertility, anovulation, PCOS, polycystic ovarian syndrome

Biographical Information about Author(s)

Abby has a special interest in internal medicine and plans on working in hospital medicine following graduation. She will be continuing her education at Butler as part of their DMS program. She will be presenting on “Management of Anovulatory Infertility due to Polycystic Ovarian Syndrome: Comparing Clomiphene Citrate and Letrozole” because she has a special interest in infertility management and treatment.

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