Faculty Sponsor

Jana Stedman

College

Nursing

Department/Program

Physician Assistant Studies

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Objective: Alzheimer’s Disease (AD) is a progressive neurocognitive disease that has effects on many different aspects of an individual’s life, if diagnosed. The purpose of this research study is to obtain data and research about the relationship between sleep and the increased risk for AD. Methods: Many different databases and resources were used in order to obtain data and studies about the subject. Of the studies used, 2 were cohort studies, 1 was a randomized control trial, 1 was a meta-analysis, and 1 was a cross-sectional study. Studies were found using PubMed, Google Scholar, and Valpo Library Summons. Primary endpoints included measuring increased Aβ and tau burden after altered sleep. Results: Results from these studies concluded that impaired sleep is associated with increased AD pathology and cognitive impairment. Similarly, research also found that quality sleep acts as a protective factor against AD. Conclusion: Sleep is a modifiable risk factor for AD. Research studies did not include long term data about how severely sleep could affect AD, therefore further research would need to be conducted in order to see these long term effects.

Keywords: Alzheimer's Disease, impaired sleep, neurocognitive degeneration, risk factor, amyloid-beta, tau neurofibrillary tangles, risk factor.

Biographical Information about Author(s)

Ziba Kisielius has a passion for the surgical field, specifically general surgery, and plans on working as a surgical PA in Chicago following graduation. She will be presenting on “Impaired Sleep as A Modifiable Risk Factor for Alzheimer’s Disease” because she has interests in neurology and progressive neurological diseases that affect cognition.

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