Faculty Sponsor

Jana Stedman

College

Nursing

Department/Program

Physician Assistant

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Purpose: When patients with polycystic ovary syndrome fail conservative options for weight loss, utilizing medications such as metformin and glucagon-like peptide-1 receptor agonists may be considered. Metformin has been the first line agent for treating weight loss and improving menstrual frequencies in polycystic ovary syndrome; however, a newer medication class, glucagon-like peptide-1 (GLP-1) receptor agonists, may be more effective.

Methods: A literature search was conducted using Google Scholar, PubMed, and Summon. There were 970 results returned, and after careful consideration, five sources were selected for this review. The studies include one single center retrospective cohort study and four systematic reviews. The studies ultimately compared weight loss, body mass index, insulin resistance levels, and menstrual frequencies. Studies must have been published between 2018 to 2023, utilized metformin and or glucagon-like peptide-1 receptor agonists as the treatment, diagnosed with polycystic ovary syndrome, and measure weight loss.

Results: Patients receiving treatment for polycystic ovary syndrome with glucagon-like peptide-1 receptor agonists had larger improvements in weight loss, body mass index reduction, and lowering insulin resistance. There was no significant difference between metformin and glucagon-like peptide-1 receptor agonists in increasing menstrual frequencies.

Conclusion: Utilizing metformin and GLP-1 are both beneficial treatment options for weight loss and increasing menstrual frequencies in patients with PCOS. GLP-1 were far more efficacious in weight loss, body mass index reduction, and lowering insulin resistance levels. There was no significant difference in improving menstrual cycle frequencies between metformin and GLP-1.

Keywords: Glucagon-like peptide-1 receptor agonists, polycystic ovary syndrome, obesity, weight loss, metformin, menstrual frequency

Biographical Information about Author(s)

Carlyn Stone has a special interest in endocrinology and plans on working in family medicine for Franciscan Health in Munster, IN following graduation. She will be presenting on “Metformin Versus GLP-1 for Therapeutic Potential in Polycystic Ovary Syndrome” because they have a special interest in predictors of success for polycystic ovary syndrome.

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