Faculty Sponsor

Jana Stedman

College

Nursing

Department/Program

Physician Assistant Program

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Objectives: This paper investigates the impact of probiotic supplementation on the gut microbiome and its correlation with the pathogenesis of polycystic ovarian syndrome (PCOS), to elucidate potential therapeutic avenues for managing PCOS-related symptoms, including insulin resistance, weight gain, irregular menstrual cycles, and infertility. Methods: The Valparaiso University online library catalog, PubMed and Google Scholar were utilized to find peer-reviewed articles and clinical trials. Sources were limited to the last five years to ensure the most recent and accurate data. Results: The diverse effects of probiotic supplementation on various endocrine markers in women with PCOS highlight the complex interactions within the endocrine system. While some studies suggest a decrease in total testosterone levels and improvements in insulin sensitivity, others show mixed results. Consistent findings indicate a decrease in fasting plasma glucose levels and potential improvements in lipid profiles with probiotic use. Clinical effects such as weight reduction, improvements in menstrual cycle regularity, and hirsutism reduction suggest promising therapeutic avenues for managing PCOS-related symptoms. However, further research is needed to clarify optimal probiotic strains, dosages, and treatment durations for maximizing clinical benefits. Conclusion: Probiotic supplementation demonstrates promising results in improving hormonal balance, metabolic parameters, and quality of life indicators among women with PCOS. These findings highlight the potential of probiotics as a complementary therapeutic approach for managing PCOS-related symptoms.

Keywords: Polycystic Ovarian Syndrome, Probiotic supplements, PCOS, Probiotics, Gut microbiome, hormonal parameters, metabolic marks, inflammatory marks, hirsutism, and menstrual irregularity.

Biographical Information about Author(s)

Cailey has a special interest in the gut microbiome and research surrounding hormonal and inflammatory biomarkers. She plans on working in Dermatology in Saint Joseph, Michigan following graduation. She will be presenting on “Probiotic Supplementation and Polycystic Ovarian Syndrome (PCOS) Management'' because PCOS is increasing in prevalence within the Dermatologic and Gynecological specialities with minimal understanding of its etiology and management options.

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