Design and Synthesis of Potential Antimicrobial Drugs

Faculty Sponsor

Jeffery Pruet

College

College of Arts & Sciences (CAS)

Discipline(s)

Chemistry

Presentation Type

Poster Presentation

Symposium Date

Spring 4-30-2026

Abstract

Microbial infections are some of the leading causes of death and antimicrobial-resistant “superbugs” have become a growing issue. There is a great need to explore new and alternative pathways for fighting these diseases. One method is by exploring Methionine synthase (MetSyn), which plays a critical role in cellular one-carbon metabolism, converting homocysteine to form methionine, a key amino acid required for protein synthesis and methyl group transfer reactions. Key differences between the B12-independant fungal MetSyn enzyme and the B12-dependant mammalian enzyme allow for selective targeting of the fungal enzyme. Inhibition of MetSyn offers a promising strategy for therapeutic and antimicrobial development. One focus of this research is the design, synthesis, and evaluation of a novel inhibitor selective for fungal MetSyn. Computational modeling and molecular docking were used to guide structural optimization of lead compounds. This interdisciplinary approach, integrating computational chemistry, organic synthesis, and quantitative chemistry, aims to elucidate the structure-activity relationships governing MetSyn inhibition. Another avenue for developing new antimicrobial drugs relies on plant-derived phytocompounds for plants with ties to traditional medicine. We have been exploring berberine, which we initially isolated from the Argemone Mexicana plant. Numerous derivatives of berberine have been prepared in our lab, with many showing improved antimicrobial effects, and greater selectivity. Ultimately, the findings of this project will contribute to the understanding of drug design and may support the development of new antimicrobial agents.

Biographical Information about Author(s)

Stephen is a junior in biochemistry with interest in medical school or a PhD in chemistry. 

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