Title
A RETINOIC ACID RESPONSIVE GENE, MK, PRODUCES A SECRETED PROTEIN A WITH HEPARIN BINDING ACTIVITY
Document Type
Article
Publication Date
January 1990
Journal Title
Biochemical and Biophysical Research Communication
Volume
171
Issue
2
Abstract
MK is a gene whose expression increases transiently during retinoic acid-induced differentiation of embryonal carcinoma cells. MK polypeptide was secreted by differentiating HM-1 embryonal carcinoma cells and by L-cells transfected with an MK cDNA under the control of the S-actin promoter and Rous sarcoma virus enhancer. MK polypeptide was found to have heparin binding activity. Conditioned medium of the transfected L-cells promoted growth of PC-12 pheochromocytoma cells. These findings support the view that MK polypeptide is a secreted factor involved in regulation of growth and differentiation.
Recommended Citation
Nakamoto, Masaru, "A RETINOIC ACID RESPONSIVE GENE, MK, PRODUCES A SECRETED PROTEIN A WITH HEPARIN BINDING ACTIVITY" (1990). Biology Faculty Publications. 50.
https://scholar.valpo.edu/bio_fac_pub/50
