Periodontal status and inflammatory markers in gingival crevicular fluid of patients with periodontitis and colorectal cancer

Authors

Sandu RâmboiuFollow
Flavia Mirela Nicolae, Craiova University of Medicine and Pharmacy, Craiova, RomaniaFollow
Andrada Soancă, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFollow
Dorin Nicolae GheorgheFollow
Dora Maria Popescu, Craiova University of Medicine and Pharmacy, Craiova, RomaniaFollow
Bogdan Silviu Ungureanu, Craiova University of Medicine and Pharmacy, Department of Gastroenterology, Craiova, RomaniaFollow
Dragoș Nicolae Mărgăritescu, Craiova University of Medicine and Pharmacy, 1st Department of Surgery, Craiova, RomaniaFollow
Adina Turcu-Știolica, Craiova University of Medicine and Pharmacy, Department of Pharmacoeconomics, Craiova, RomaniaFollow
Mihail Virgil Boldeanu, Craiova University of Medicine and Pharmacy, Department of Immunology, Craiova, RomaniaFollow
Valeriu Marin Șurlin, Craiova University of Medicine and Pharmacy, 1st Department of Surgery, Craiova, RomaniaFollow
Dan Ionuț Gheonea, Craiova University of Medicine and Pharmacy, Department of Gastroenterology, Craiova, RomaniaFollow
Petra Șurlin, Craiova University of Medicine and Pharmacy, Department of Periodontology, Craiova, RomaniaFollow

Abstract

Objectives. The present pilot study was carried out to evaluate the periodontal status, the levels of interleukin-6 and tumor necrosis factor alpha in gingival crevicular fluid on hospitalized patients with colorectal cancer. Materials and Methods. The sample of our study was represented by 74 patients with colorectal cancer. They were assigned to one of the two study groups, based on cancer’s stages, as follows: (i) stage III-IV: 51 patients (A-group); (ii) stage I-II: 23 patients (B-group). For each participant periodontal parameters were recorded and gingival crevicular fluid samples were collected and immunologically assessed. Results. Statistically significant differences were found between the two groups, regarding probing pocket depth, clinical attachment loss, bleeding on probing, interleukin-6 and tumor necrosis factor alpha. In A-group, statistically significant correlations were found between the inflammatory markers and probing pocket depth and between their levels and bleeding on probing. In B-group, statistically significant correlation was found between the levels of interleukin-6 and bleeding on probing. Conclusions. Our results suggest an association between the severity of periodontitis, the studied immunologic inflammatory markers and colorectal cancer’s severity.

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Recommended Citation

Râmboiu, Sandu; Nicolae, Flavia Mirela; Soancă, Andrada; Gheorghe, Dorin Nicolae; Popescu, Dora Maria; Ungureanu, Bogdan Silviu; Mărgăritescu, Dragoș Nicolae; Turcu-Știolica, Adina; Boldeanu, Mihail Virgil; Șurlin, Valeriu Marin; Gheonea, Dan Ionuț; and Șurlin, Petra (2023) "Periodontal status and inflammatory markers in gingival crevicular fluid of patients with periodontitis and colorectal cancer," Journal of Mind and Medical Sciences: Vol. 10: Iss. 2, Article 20.
DOI: https://doi.org/10.22543/2392-7674.1429
Available at: https://scholar.valpo.edu/jmms/vol10/iss2/20