Faculty Sponsor

Jana Stedman

College

College of Nursing & Health Professions (CONHP)

Department/Program

Physician Assistant Program

Presentation Type

Poster Presentation

Symposium Date

7-23-2025

Abstract

Objective: This study aims to evaluate whether post-operative adjunctive radiotherapy (PORT) reduces recurrence rates and improves overall survival (OS) in patients diagnosed with grade II/atypical meningiomas (AMs).

Methods: A systematic search was conducted using Google Scholar with primary search terms including “meningiomas,” “surgical resection,” and “radiotherapy,” yielding 4,830 results. Inclusion criteria were limited to peer-reviewed articles published in English from 2019 or later. Studies published before 2019 or in non-English languages were excluded. Key outcomes analyzed included recurrence rates, progression-free survival (PFS), and overall survival.

Results: Evidence suggests that PORT following gross total resection (GTR) of AMs does not significantly improve PFS or OS. However, for patients undergoing subtotal resection (STR), PORT is associated with improved 5-year PFS but does not show a corresponding improvement in OS.

Conclusion: Adjunctive radiotherapy may offer clinical benefit in reducing recurrence and extending progression-free survival in patients with AMs who undergo STR or present with high-risk features. In contrast, for patients with low-risk AMs who have received GTR, PORT does not significantly impact recurrence rates or overall survival and may not be routinely indicated.

Keywords: atypical meningioma, adjunctive radiotherapy, gross total resection, subtotal resection, progression-free survival, recurrence rate

Biographical Information about Author(s)

Madison Janickovic has an anticipated graduation date of July 2025 from the Valparaiso University Physician Assistant Program. Her favorite rotation was Pediatrics due to the wide variety of appointments from annual well-child to sick visits. She plans on working in pediatrics or pediatric orthopedics after graduating. Her favorite memory from clinical rotations this year was being able to assist in brain surgeries. Madison was inspired to research the topic of “Adjunctive Radiotherapy in the Management of Meningiomas” due to her longstanding interest in the brain. She would like to thank her professors, preceptors, and family for supporting her throughout her education.

Download

Share

COinS