Evolving Treatment Strategies for Moderate-to-Severe Hidradenitis Suppurativa

Faculty Sponsor

Jana Stedman

College

College of Nursing & Health Professions (CONHP)

Department/Program

MSPA Program or Physician's Assistant Program

Presentation Type

Poster Presentation

Symposium Date

Summer 7-13-2025

Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder that severely impacts quality of life, yet consensus on optimal long-term treatment remains limited. The significance of this issue stems from the ongoing reliance on antibiotics, despite concerns regarding resistance and limited long-term efficacy. This study aimed to compare the effectiveness of biologic therapies, particularly Adalimumab, with traditional antibiotic regimens in treating moderate-to-severe HS over a one-year period. The hypothesis proposed that biologics offer improved symptom control, fewer flare-ups, and greater patient satisfaction. A comprehensive literature review was conducted using Medline via the Christopher Center and Google Scholar, yielding 77 and over 20,000 results, respectively. Studies were included if they involved patients diagnosed with HS; those focused on acne vulgaris were excluded. Data analysis focused on clinical outcomes and patient-reported satisfaction. Findings showed that although antibiotics remain the primary systemic treatment, their long-term benefits are limited and may delay more effective options. Biologics, while effective and targeting underlying inflammatory mechanisms, are underutilized and often initiated years after diagnosis. Patient preference for oral medications and limited access to biologics contribute to delayed use. The review concludes that biologics demonstrate equal or superior efficacy and should be considered earlier in treatment. However, more research is needed to establish standardized treatment protocols, assess long-term outcomes, and explore barriers to early biologic use in HS management.

Abstract Image

Biographical Information about Author(s)

Rachael has a special interest in practicing as a physician assistant in family and pediatric medicine and plans on working in the Northwest, Indiana region following graduation. She intends on working for a federally qualified health center in efforts to bring care to those who have difficulty accessing it. She will be presenting “Evolving Treatment Strategies for Moderate-to-Severe Hidradenitis Suppurativa” as she saw this condition frequently through her experiences within her clinical year.

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