Faculty Sponsor

Jana Stedman

College

Nursing

Department/Program

Master of Physician Assistant Studies

Presentation Type

Poster Presentation

Symposium Date

Summer 7-24-2024

Abstract

Objectives. This research aims to evaluate the efficacy of venovenous extracorporeal membrane oxygenation in patients suffering from severe acute respiratory distress syndrome in comparison to the mortality rate of ARDS patients who receive low tidal volume mechanical ventilation.

Methods. Online databases included Ebsco Host, PubMed, DynaMed, UpToDate, and Cochrane Library. Date limitations were from 2018 through the present. Results were filtered using ‘peer-reviewed journals,’ ‘full text available,’ ‘meta-analyses,’ ‘systematic reviews,’ ‘cohort studies,’ and ‘retrospective literature reviews.’ A total of 6,820 results were returned, including the investigation of ARDS. Six studies were chosen to investigate therapeutic management, including one prospective multi-centered randomized control trial, three retrospective cohort analyses, and two meta-analyses to compare venovenous extracorporeal lung support against mechanical ventilation for ARDS.

Results. Two of the six studies were in favor of ECMO therapy, demonstrating decreased mortality at one year. Three studies highlighted a crucial issue with a lack of data collection for patient follow-up who received ECMO. This lack of follow-up would confound the results of ECMO therapy.

Conclusion. Extracorporeal lung support measures in severe ARDS remain a subject of debate when compared to low tidal volume mechanical ventilation. ECMO, however, has a proven benefit in terms of survival and mortality rate with early cannulation. It is crucial to remember that ECMO is a resource-intensive intervention requiring specialized management training to address potential adverse effects. Therefore, its utilization in ARDS should be approached on an individual basis.

Keywords: Acute respiratory distress syndrome, venovenous ECMO, survival,

mechanical ventilation, mortality, complications

Biographical Information about Author(s)

Patrick Manyek is interested in Critical Care and Pulmonary Medicine and plans to attend a Critical Care Fellowship with the Medical College of Wisconsin after graduation. He plans to continue his research on ECMO and its utilization in cardiopulmonary medicine and eventually publish his work. Patrick will be presenting on “Determining Therapeutic Efficacy of Venovenous Extracorporeal Lung Support in Acute Respiratory Distress Syndrome Patients.”

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