Vitamin D Insufficiency and Coronary Artery Disease
Master of Science in Physician Assistant Studies
Objective: The objective of this research is to determine if patients with a vitamin D insufficiency have an increased risk of coronary artery disease when compared to patients with optimal vitamin D levels.
Methods: Two data bases, PubMed and Science Direct were searched for studies evaluating vitamin D levels and coronary artery disease. After applying an inclusion and exclusion criteria there were a total of five studies which included a total of 4,925 participants that met criteria and analyzed the relationship of vitamin D and heart disease.
Results: Deficient vitamin D levels are negatively correlated with coronary artery disease and specifically the severity of coronary artery disease. Vitamin D levels are also inversely related to homocysteine levels, which play a role in the development of heart disease when increased.
Conclusion: Patients with coronary artery disease had decreased levels of vitamin D when compared to control patients with less severe disease or no coronary artery disease. Although significant, large, longitudinal clinical experiments are needed to establish the optimal dose and duration of supplementation for cardiovascular protection.
Keywords: (1) Vitamin D Deficiency (2) Vitamin D Insufficiency (3) 25-Hydroxyvitmain D (4) Heart Disease (5) Coronary Artery Disease
Koontz, Alexandra, "Vitamin D Insufficiency and Coronary Artery Disease" (2023). Summer Interdisciplinary Research Symposium. 166.