Abstract
Epidermolysis bullosa (EB) is a rare, serious genetic disease, incurable through the current means. Apart from this initial definition, there was later some ease in the definition of the disease, including the manifestations of toxic epidermal necrolysis and Stevens Johnson syndrome in this entity. In medical practice, there are cases that do not overlap with the description in the literature, thus the treatment must be adapted and personalized to the particularities. We present the case of a female new-born, with "de novo" mutation for the early-onset antenatal epidermolysis and our personalized therapeutic management, based on collagen from bovine corneas by enzymatic process. The histological examination showed that the collagen membranes serve as a support for the epithelial cells that formed a surface monolayer after 48 hours. Therefore. this case report shows that collagen-based biomaterials could be used to accelerate the dermal-epidermal healing in various conditions of the child, such as Stevens Johnson syndrome, bullous epidermolysis and widespread burns.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Nedelcuţă, Ramona Mihaela; Călin, Gigi; Nedelcuţă, Mihai Cristian; Baleanu, Vlad Dumitru; Davitoiu, Dragos Virgil; Socea, Bogdan; and Stănoiu, Bogdan-Petre
(2021)
"Collagen-based biomaterials with possible therapeutic effects,"
Journal of Mind and Medical Sciences: Vol. 8:
Iss.
2, Article 23.
DOI: https://doi.org/10.22543/7674.82.P324329
Available at:
https://scholar.valpo.edu/jmms/vol8/iss2/23
Included in
Dermatology Commons, Medical Genetics Commons, Natural Products Chemistry and Pharmacognosy Commons, Pediatrics Commons, Plastic Surgery Commons, Skin and Connective Tissue Diseases Commons