The molecular mechanisms linking metabolic syndrome to endometrial and breast cancers

Authors

Andrada-Luciana Lazar, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF DERMATOLOGY, CLUJ-NAPOCA, ROMANIA
Romana Vulturar, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF MOLECULAR SCIENCES, CLUJ-NAPOCA, ROMANIA
Adriana Fodor, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, CLINICAL CENTER OF DIABETES, NUTRITION, METABOLIC DISEASES, CLUJ-NAPOCA, ROMANIA
Olga Hilda Orasan, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, 4TH MEDICAL CLINIC, CLUJ-NAPOCA, ROMANIAFollow
Camil-Horia Eusebiu Crișan, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, CLUJ-NAPOCA, ROMANIA
Cezar Login, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PHYSIOLOGY, CLUJ-NAPOCA, ROMANIA
Ioana Para, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, 4TH MEDICAL CLINIC, CLUJ-NAPOCA, ROMANIA
Vasile Negrean, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, 4TH MEDICAL CLINIC, CLUJ-NAPOCA, ROMANIA
Brandusa Tiperciuc, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PHARMACEUTICAL CHEMISTRY, CLUJ-NAPOCA, ROMANIA
Angela Cozma, IULIU HAŢIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, 4TH MEDICAL CLINIC, CLUJ-NAPOCA, ROMANIA

Abstract

The metabolic syndrome represents a plethora of cardio-metabolic risk factors including obesity, arterial hypertension, atherogenic dyslipidemia, hyperglycemia, accompanied by pro-inflammatory and pro-thrombotic state. The metabolic syndrome is one of the key risk factors for certain types of cancer. Among these malignancies, breast cancer and endometrial neoplasms require special attention. Incriminated major causes for the development of breast and endometrial cancer in metabolic syndrome patients are: the pro-inflammatory status and related cytokines, adipokine imbalances, hyperestrogenism, growth factors, disturbances in cancer microenvironment, insulin resistance and hyperinsulinemia. The metabolic syndrome consists of molecular dysregulations that create a pro-oncogenic status. Our review aims at providing a better understanding of the mechanisms underlying the link between the metabolic syndrome and endometrial and breast cancer.

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Recommended Citation

Lazar, Andrada-Luciana; Vulturar, Romana; Fodor, Adriana; Orasan, Olga Hilda; Crișan, Camil-Horia Eusebiu; Login, Cezar; Para, Ioana; Negrean, Vasile; Tiperciuc, Brandusa; and Cozma, Angela (2021) "The molecular mechanisms linking metabolic syndrome to endometrial and breast cancers," Journal of Mind and Medical Sciences: Vol. 8: Iss. 2, Article 2.
DOI: https://doi.org/10.22543/7674.82.P167178
Available at: https://scholar.valpo.edu/jmms/vol8/iss2/2