Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis

Authors

Victoria Maria Ruta, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, CLUJ NAPOCA, ROMANIA
Teodora Gabriela Alexescu, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF INTERNAL MEDICINE, CLUJ NAPOCA, ROMANIA
Ana Rodica Ungur, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF MEDICAL REHABILITATION, CLUJ NAPOCA, ROMANIA
Milena Adina Man, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PNEUMOLOGY, CLUJ NAPOCA, ROMANIA
Victoria Georgiana Sfirlea, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PNEUMOLOGY, CLUJ NAPOCA, ROMANIA
Iulia Olimpia Pfingstgraf, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PATHOPHYSIOLOGY, CLUJ NAPOCA, ROMANIA
Nicoleta Motoc, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PNEUMOLOGY, CLUJ NAPOCA, ROMANIA
Carmen Monica Pop, IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PNEUMOLOGY, CLUJ NAPOCA, ROMANIA

Abstract

Lungs have long been considered sterile, but recent research has shown that a large number of microbiological organisms exist in the lungs of healthy subjects (including bacteria, fungi, and viruses), collectively known as the microbiome. It undergoes changes in patients with respiratory pathology. Studies in idiopathic pulmonary fibrosis show that a large number of bacteria or the abundant presence of potentially pathogenic bacteria can cause disease progression and exacerbation, and can implicitly increase mortality. There seems to be a quantitative balance, a well-established proportion between the components of this microbiome, which is disturbed during a disease and can reach a "state of pulmonary dysbiosis". Evidence suggests that the microbiome may be used as a prognostic biomarker and may also explain the pathogenesis of interstitial fibrosis.

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Recommended Citation

Ruta, Victoria Maria; Alexescu, Teodora Gabriela; Ungur, Ana Rodica; Man, Milena Adina; Sfirlea, Victoria Georgiana; Pfingstgraf, Iulia Olimpia; Motoc, Nicoleta; and Pop, Carmen Monica (2020) "Composition and modification of the lung microbiome in patients with idiopathic pulmonary fibrosis," Journal of Mind and Medical Sciences: Vol. 7: Iss. 2, Article 6.
DOI: https://doi.org/10.22543/7674.72.P162167
Available at: https://scholar.valpo.edu/jmms/vol7/iss2/6