Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update

Authors

Sorina Cezara Coste, uliu Hatieganu University of Medicine and Pharmacy, 4th Medical Clinic, Department no. 5 of Internal Medicine, Cluj-Napoca, RomaniaFollow
Ionela Popovici, uliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, RomaniaFollow
Andreea Maria Stefan, Regional Institute of Gastroenterology and Hepatology `Prof. Dr. Octavian Fodor`, Cluj-Napoca, RomaniaFollow
Iulia Breaban, Regional Institute of Gastroenterology and Hepatology `Prof. Dr. Octavian Fodor`, Cluj-Napoca, RomaniaFollow
Adela Sitar Taut, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, RomaniaFollow
Simina Tarmure Sarlea, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, RomaniaFollow
Angela Cozma, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, RomaniaFollow
Dorel Sampelean, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, Romania
Olga Hilda Orasan, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, RomaniaFollow
Vasile Negrean, Iuliu Hatieganu University of Medicine and Pharmacy, 4th Medical Department, Cluj-Napoca, Romania
Lucia Maria Procopciuc, Iuliu Hatieganu University of Medicine and Pharmacy, 3rd Department Molecular Sciences, Medical Biochemistry, Cluj-Napoca, RomaniaFollow

Abstract

Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome. Chronic inflammation of the liver is an essential key in the progression from simple hepatic steatosis to steatohepatitis, the evolutionary stage of fatty liver disease. Moreover, the innate immune system plays a crucial role in the progression of hepatic inflammation. For this reason, it is of utmost importance to elucidate the connections between immune mechanisms, Toll-like receptor cytokine signalling, in order to find new effective treatments. Further studies are necessary to test theories presented in this paper. The elucidation of mechanisms underlying the progression of hepatic steatosis towards steatohepatitis is essential for the development of useful diagnosis and treatment for medical practice.

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Recommended Citation

Coste, Sorina Cezara; Popovici, Ionela; Stefan, Andreea Maria; Breaban, Iulia; Sitar Taut, Adela; Tarmure Sarlea, Simina; Cozma, Angela; Sampelean, Dorel; Orasan, Olga Hilda; Negrean, Vasile; and Procopciuc, Lucia Maria (2019) "Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update," Journal of Mind and Medical Sciences: Vol. 6: Iss. 1, Article 10.
DOI: https://doi.org/10.22543/7674.61.P5257
Available at: https://scholar.valpo.edu/jmms/vol6/iss1/10