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Authors

Olga Hilda Orasan, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, RomaniaFollow
Andreea Maria Stefan, Prof. Dr. Octavian Fodor, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Laura Urian, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Department of Hematology, Cluj- Napoca, Romania
Anca Mihailov, Railway Hospital, 4th Surgical Department, Cluj-Napoca, Romania
Ovidiu Fabian, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Surgery, Cluj- Napoca, Romania
Flaviu Muresan, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Surgery, Cluj- Napoca, Romania
Iulia Breaban, Prof. Dr. Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
Sorina Cezara Secara, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, Cluj-Napoca, Romania
Simina Tarmure Sarlea, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania
Vasile Negrean, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania
Dorel Sampelean, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania
Angela Cozma, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4th Department of Internal Medicine, Cluj-Napoca, Romania

DOI

10.22543/7674.52.P300304

Abstract

We present the case of a 46-year old patient with Child-Pugh class C cirrhosis with MEDL-Score 16, and hepatocellular carcinoma invading the inferior vena cava and the right atrium. The etiology of cirrhosis is type 1 hereditary hemochromatosis with positive HFE C282Y/C282Y and H63D/H63D mutations. A systematic review of the literature was performed and only 30 cases of hepatocellular carcinoma with tumor thrombosis extending into the right atrium have been described. To our knowledge, this is the first case that evidences the presence in hereditary hemochromatosis of hepatocellular carcinoma with atypical invasion into the right atrium. Screening of patients with a family history of hereditary hemochromatosis allows detection of the disease in the asymptomatic phase, allowing initiation of early therapy and improved prognosis.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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