Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Authors

Olga Hilda Orasan, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Laura Urian, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Department of Hematology, Cluj-Napoca, RomaniaFollow
George Ciulei, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Iulia Breaban, Regional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, RomaniaFollow
Andreea Maria Stefan, Regional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, RomaniaFollow
Sorina Cezara Secara, Regional Institute of Gastroenterology and Hepatology- Prof. Dr. Octavian Fodor, Cluj-Napoca, RomaniaFollow
Adela Sitar Taut, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Simina Tarmure Sarlea, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Vasile Negrean, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Dorel Sampelean, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow
Ioan Mihai Patiu, Nefromed Dialysis Centers, Cluj-Napoca, RomaniaFollow
Remus Aurel Orasan, Nefromed Dialysis Centers,Cluj-Napoca, RomaniaFollow
Angela Cozma, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Medical Department, Cluj-Napoca, RomaniaFollow

Abstract

Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis.

Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients without hepatitis.

Results. The presence of viral hepatitis was associated with a higher prevalence of thrombocytopenia. Correlations between age, C-reactive protein, liver stiffness measurement, and platelet count were observed. C-reactive protein levels > 10 mg/dl were associated with a lower risk of thrombocytopenia in patients with end-stage renal disease and chronic viral hepatitis, yet age > 60 years, dialysis vintage > 10 years, aspartate and alanine aminotransferase levels > 20 IU/L, albumin levels < 3.5 g/dl, and fibrosis stage ≥ 3 were not related.

Conclusions. Chronic viral hepatitis leads to a higher prevalence of thrombocytopenia. Platelet counts in these patients begin to decrease significantly once liver fibrosis reaches stage III.

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Recommended Citation

Orasan, Olga Hilda; Urian, Laura; Ciulei, George; Breaban, Iulia; Stefan, Andreea Maria; Secara, Sorina Cezara; Sitar Taut, Adela; Tarmure Sarlea, Simina; Negrean, Vasile; Sampelean, Dorel; Patiu, Ioan Mihai; Orasan, Remus Aurel; and Cozma, Angela (2018) "Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C," Journal of Mind and Medical Sciences: Vol. 5: Iss. 2, Article 14.
DOI: https://doi.org/10.22543/7674.52.P236243
Available at: https://scholar.valpo.edu/jmms/vol5/iss2/14