Clinical-evolutional particularities of the cryoglobulinemic vasculitis in the case of a patient diagnosed with hepatitis C virus in the predialitic phase

Authors

Daniel C. Caragea, Emergency County Hospital of SlatinaFollow
Larisa Săndulescu, Craiova University of Medicine and Pharmacy, Department of GastroenterologyFollow
Vlad Pădureanu, Craiova University of Medicine and Pharmacy, Department of Internal MedicineFollow
Mircea C. Forțofoiu, Craiova University of Medicine and Pharmacy, Department of Internal MedicineFollow
Costin Streba, Craiova University of Medicine and Pharmacy, Department of GastroenterologyFollow
Lidia Boldeanu, Craiova University of Medicine and Pharmacy, Department of MicrobiologyFollow
Mihail V. Boldeanu, Craiova University of Medicine and Pharmacy, Department of Immunology - Laboratory of ImmunologyFollow
Mircea Popescu-Drigă, Craiova University of Medicine and Pharmacy, Department of Immunology - Laboratory of ImmunologyFollow
Marius E. Ciurea, Craiova University of Medicine and Pharmacy, Department of Plastic SurgeryFollow
Maria Forțofoiu, Craiova University of Medicine and Pharmacy, Deparment of Emergency MedicineFollow
Ion Rogoveanu, Craiova University of Medicine and Pharmacy, Department of GastroenterologyFollow
Tudorel Ciurea, Craiova University of Medicine and Pharmacy, Department of GastroenterologyFollow
Cristin C. Vere, Craiova University of Medicine and Pharmacy, Department of GastroenterologyFollow

Abstract

Hepatitis C virus (HCV) represents a fundamental issue for public health, with long term evolution and the gradual appearance of several complications and associated pathologies. One of these pathologies is represented by cryoglobulinemic vasculitis, a disorder characterized by the appearance in the patient’s serum of the cryoglobulins, which typically precipitate at temperatures below normal body temperature (37°C) and dissolve again if the serum is heated. Here, we describe the case of a patient diagnosed with HCV that, during the evolution of the hepatic disease, developed a form of cryoglobulinemic vasculitis. The connection between the vasculitis and the hepatic disorder was revealed following treatment with interferon, with the temporary remission of both pathologies and subsequent relapse at the end of the 12 months of treatment, the patient becoming a non-responder. The particularity of the case is represented by both the severity of the vasculitic disease from its onset and the deterioration of renal function up to the predialitic phase, a situation not typical of the evolution of cryoglobulinemia. Taking into account the hepatic disorder, the inevitable evolution towards cirrhosis, and the risk of developing the hepatocellular carcinoma, close monitoring is necessary.

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Recommended Citation

Caragea, Daniel C.; Săndulescu, Larisa; Pădureanu, Vlad; Forțofoiu, Mircea C.; Streba, Costin; Boldeanu, Lidia; Boldeanu, Mihail V.; Popescu-Drigă, Mircea; Ciurea, Marius E.; Forțofoiu, Maria; Rogoveanu, Ion; Ciurea, Tudorel; and Vere, Cristin C. (2018) "Clinical-evolutional particularities of the cryoglobulinemic vasculitis in the case of a patient diagnosed with hepatitis C virus in the predialitic phase," Journal of Mind and Medical Sciences: Vol. 5: Iss. 1, Article 21.
DOI: https://doi.org/10.22543/7674.51.P135140
Available at: https://scholar.valpo.edu/jmms/vol5/iss1/21