Efficacy of tranexamic acid in nasopharyngeal hemorrhage; single center prospective study and literature review

Authors

Septar Haldun, Ovidius University, Faculty of Medicine, Department of Otorhynolaryngology, Constanta, RomaniaFollow
Andra-Iulia Suceveanu, Ovidius University, Faculty of Medicine, Department of Gastroenterology, Constanta, RomaniaFollow
Mihai Lupascu, Ovidius University, Faculty of Medicine, Department of Otorhynolaryngology, Constanta, RomaniaFollow
Laura Mazilu, Ovidius University, Faculty of Medicine, Department of Oncology, Constanta, RomaniaFollow
Alina Nicoara, Ovidius University, Faculty of Medicine, Department of Internal Medicine, Constanta, RomaniaFollow
Viorel Gherghina, Ovidius University, Faculty of Medicine, Department of Intensive Care, Constanta, RomaniaFollow
Felix Voinea, Ovidius University, Faculty of Medicine, Department of Urology, Constanta, RomaniaFollow
Razvan Hainarosie, Carol Davila University of Medicine and Pharmacy, Department of Otorhynolaryngology, Bucharest, RomaniaFollow
Alexandru Aristide Alexe, Ovidius University, Faculty of Medicine, Department of Otorhynolaryngology, Constanta, RomaniaFollow
Ana Maria Dascalu, Carol Davila University of Medicine and Pharmacy, Department of Ophthalmology, Bucharest, RomaniaFollow
Adrian Paul Suceveanu, Ovidius University, Faculty of Medicine, Department of Gastroenterology, Constanta, RomaniaFollow

Abstract

Nasopharyngeal hemorrhage is one of the most common ear, nose, and throat (ENT) emergencies that present in a hospital or primary care clinic. While many cases of hemorrhage are self-limiting, in more severe cases medical intervention is necessary, either to cauterize the bleeding vessel or to pack the nose with various materials (thus involving specialized medical care and time, which implicitly lead to additional costs). In the case of the packaging, the medical treatment can in some cases be extremely painful and unpleasant. Tranexamic acid is an affordable, inexpensive, easy-to-use antifibrinolytic agent and with no notable side effects, as demonstrated by numerous studies related to most surgical fields. The aim of this paper is to provide an evidence-based approach to the use of tranexamic acid (TXA) in nasopharyngeal hemorrhages in our research center, comparing with the available literature on the subject, but presented in an updated form. As a conclusion, the combined use (intravenous and topical) of TXA may be a reasonable, safe and non-invasive option for hemodynamic stabilization of rhino-pharyngeal bleeding.

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Recommended Citation

Haldun, Septar; Suceveanu, Andra-Iulia; Lupascu, Mihai; Mazilu, Laura; Nicoara, Alina; Gherghina, Viorel; Voinea, Felix; Hainarosie, Razvan; Alexe, Alexandru Aristide; Dascalu, Ana Maria; and Suceveanu, Adrian Paul (2024) "Efficacy of tranexamic acid in nasopharyngeal hemorrhage; single center prospective study and literature review," Journal of Mind and Medical Sciences: Vol. 11: Iss. 1, Article 24.
DOI: https://doi.org/10.22543/2392-7674.1469
Available at: https://scholar.valpo.edu/jmms/vol11/iss1/24