Abstract
Colon cancer is relatively asymptomatic in the early stages, the manifestations appearing and intensifying with the evolution of the disease, especially when associated with local and/or systemic complications. In such cases, surgical interventions are often emergency and involve more extensive operations (on metabolically and immune-stressed organisms), so that an early diagnosis (endoscopy, tumor markers, etc.) remains not only desirable but even a priority, especially in predisposed patients (genetic factors, lifestyle, etc.). As a consequence, the involvement of tumor markers in colon neoplasms has become more and more investigated in recent times. This review investigates the roles of serological and genetic markers in the management of patients with colon cancer, focusing on carcinoembryonic antigen, mismatch repair deficiency (dMMR), as well as KRAS and BRAF mutations. As a preliminary conclusion, tumor biomarkers seem to have a significant contribution to the diagnosis, decisions related to operative management, prognosis and postoperative follow-up of colon cancer, both in the categories of patients from high-risk groups and those without a clear predisposition to this condition.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Silaghi, Adrian; Constantin, Vlad Denis; Serban, Dragos; Epistatu, Dragos; Paunica, Ioana; Bălan, Daniela Gabriela; and Rebegea, Laura Florentina
(2024)
"Genetic and serological markers in colorectal cancer surgery,"
Journal of Mind and Medical Sciences: Vol. 11:
Iss.
1, Article 11.
DOI: https://doi.org/10.22543/2392-7674.1474
Available at:
https://scholar.valpo.edu/jmms/vol11/iss1/11
Included in
Gastroenterology Commons, Genetic Phenomena Commons, Medical Immunology Commons, Oncology Commons, Surgery Commons