Effect of continuous renal replacement therapy on serum levels of inflammatory cytokines/interleukin-17 in severe acute pancreatitis

Authors

Diana Iosif, Ovidius University of Constanta, Doctoral School of Medicine, Constanta, RomaniaFollow
Adrian Paul Suceveanu, Ovidius University of Constanta, Faculty of Medicine, Department of Gastroenterology, Constanta, RomaniaFollow
Marius Prazaru, St Andrew Apostle Emergency Hospital, Department of Intensive Care Unit, Constanta, RomaniaFollow
Iulia Cindea, Ovidius University of Constanta, Faculty of Medicine, Department of Intensive Care Unit, Constanta, RomaniaFollow
Viorel Gherghina, Ovidius University of Constanta, Faculty of Medicine, Department of Intensive Care Unit, Constanta, RomaniaFollow
Anca Mihaela Pantea Stoian, Carol Davila University of Medicine and Pharmacy, N.C. Paulescu National Institute of Diabetes, Bucharest, RomaniaFollow
Laura Mazilu, Ovidius University of Constanta, Doctoral School of Medicine, Constanta, RomaniaFollow
Dragos Serban, Carol Davila University of Medicine and Pharmacy, Emergency University Hospital, Department of General Surgery, Bucharest, RomaniaFollow
Alina Nicoara, Ovidius University of Constanta, Faculty of Medicine, Department of Internal Medicine, Constanta, RomaniaFollow
Andra Iulia Suceveanu, Ovidius University of Constanta, Faculty of Medicine, Department of Intensive Care Unit, Constanta, RomaniaFollow

Abstract

Despite continuous investigations in the diagnosis and treatment of severe acute pancreatitis (SAP), this disease still remains a critical condition with a mortality rate of up to 35%. The pathophysiology of SAP involves an important inflammatory reaction of the pancreas (mediated by inflammatory cytokines and immune system activation), causing severe local tissue damage as well as important systemic imbalances. IL-17 is an inflammatory mediator that have a pivotal role in SAP evolution, generating multiple interactions between inflammatory cytokines and significantly influencing the immune system response. Consequently, continuous renal replacement therapy/CRRT was added to the conventional therapy, leading to improved treatment results. This review aims to evaluate the involvement of Interleukin 17 in the diagnosis, pathogenesis and evolution of SAP, as well as the role of CRRT in reducing elevated serum levels of IL-17. As a conclusion, CRRT is a promising method to eliminate cytokine mediators from the blood, thus leading to a reduction of both pancreatic/peripancreatic tissue damage and systemic imbalances in severe acute pancreatitis, being strongly correlated with better therapeutic outcomes.

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Recommended Citation

Iosif, Diana; Suceveanu, Adrian Paul; Prazaru, Marius; Cindea, Iulia; Gherghina, Viorel; Pantea Stoian, Anca Mihaela; Mazilu, Laura; Serban, Dragos; Nicoara, Alina; and Suceveanu, Andra Iulia (2024) "Effect of continuous renal replacement therapy on serum levels of inflammatory cytokines/interleukin-17 in severe acute pancreatitis," Journal of Mind and Medical Sciences: Vol. 11: Iss. 1, Article 10.
DOI: https://doi.org/10.22543/2392-7674.1476
Available at: https://scholar.valpo.edu/jmms/vol11/iss1/10