Primary Submission Contact
Jeffrey Pruet
Faculty Sponsor
Jeffrey Pruet
Faculty Sponsor Email Address
jeffrey.pruet@valpo.edu
College
Arts and Sciences
Department/Program
Chemistry
Document Type
Poster Presentation
Date
Fall 10-27-2017
Abstract
Methionine Synthase (MetSyn) is an essential enzyme for all organisms. Taking advantage of key differences between fungal MetSyn and mammalian MetSyn, an antifungal drug could be developed to exclusively inactivate the fungal cell while leaving the host (patient) unaffected. To develop an inhibitor of fungal MetSyn we have begun the synthesis on two molecules which mimic folate, a necessary compound for MetSyn to function.
Recommended Citation
Pruet, Jeffrey and Grumbles, Kassidy, "Synthesizing New Molecules for an Antifungal Drug" (2017). Fall Interdisciplinary Research Symposium. 81.
https://scholar.valpo.edu/fires/81
