Partial Synthesis of an Unnatural Fluorescent Amino Acid
Primary Submission Contact
Arman Salim
Faculty Sponsor
Thomas Goyne
Faculty Sponsor Email Address
thomas.goyne@valpo.edu
College
Arts and Sciences
Department/Program
Biochemistry
Document Type
Poster Presentation
Date
Fall 10-30-2015
Abstract
Unnatural fluorescent amino acids are important tools that allow biochemists to visualize proteins in living cells. The addition of an unnatural fluorescent amino acid makes these normally transparent proteins, glow-in-the-dark. The goal of this research is to synthesize a benzoxadiazole-based fluorescent amino acid. After numerous failed attempts to complete the key coupling step using nucleophilic aromatic substitution, a palladium catalyst was found to yield the desired product. Once the synthesis of this fluorescent amino acid is complete, a screening system will be used to determine whether or not it can be incorporated into proteins.
Recommended Citation
Salim, Arman D. and Goyne, Thomas, "Partial Synthesis of an Unnatural Fluorescent Amino Acid" (2015). Fall Interdisciplinary Research Symposium. 41.
https://scholar.valpo.edu/fires/41
