Development of EDTA Crosslinked Beta-Cyclodextrin for Use in Drug-Eluting Cardiovascular Stents
Primary Submission Contact
Grace Burkhart
Faculty Sponsor
Dr. Jennifer Holt
Faculty Sponsor Email Address
jennifer.holt@valpo.edu
College
Arts and Sciences
Department/Program
Chemistry
Document Type
Poster Presentation
Date
Fall 10-25-2019
Abstract
Drug-eluting stents (DES) reduce the occurrence of in-stent restenosis in patients who have a stent placed in cardiac arteries. However, current DES do not have a long enough window of drug release to prevent late in-stent restenosis. Beta-cyclodextrin (BCD), a polymer which is capable of drug elution, has a high biocompatibility, and is able to be refilled with drug, is polymerized using Ethylenediaminetetraacetic acid (EDTA). The EDTA-BCD polymer particles have shown good attachment on Cobalt Chromium cardiovascular stents through imaging with SEM and analysis with EDS. Drug release studies done on the particles have shown extended drug release, showing that EDTA-BCD polymers have the capability of being a refillable and biocompatible coating for cardiovascular stents that can reduce the occurrence of late in-stent restenosis.
Recommended Citation
Burkhart, Grace; Young, Kathleen; Mu, Nathan; and von Recum, Horst A., "Development of EDTA Crosslinked Beta-Cyclodextrin for Use in Drug-Eluting Cardiovascular Stents" (2019). Fall Interdisciplinary Research Symposium. 130.
https://scholar.valpo.edu/fires/130
Additional Presentation Information
Wall Poster
Biographical Information about Author(s)
Grace Burkhart is a senior at Valparaiso University, and spent the summer researching with Kathleen Young and Nathan Mu in Professor Horst von Recum's lab at Case Western Reserve University.