Faculty Sponsor
Dr. Kevin Jantzi
College
Arts and Sciences
Discipline(s)
Chemistry
Presentation Type
Poster Presentation
Symposium Date
Spring 5-3-2019
Abstract
Pd(0)-catalyzed trimethylenemethane (TMM) cycloaddition reactions have been used extensively to generate disubstituted 5-membered rings with high levels of regioselectivity, chemoselectivity, and stereoselectivity. We aim to improve upon existing methodologies by introducing an epoxide into the TMM precursor, which should yield more highly functionalized products. A three step synthesis of a TMM precursor has been achieved in 20% overall yield. Efforts are underway to determine the reactivity of this precursor in Pd(0)-catalyzed cycloaddition reactions with substituted alkenes.
Recommended Citation
Paterson, Mara, "Development of a Novel Epoxide-Containing Trimethylenemethane Precursor for Palladium-Catalyzed Cycloadditions" (2019). Symposium on Undergraduate Research and Creative Expression (SOURCE). 837.
https://scholar.valpo.edu/cus/837
Biographical Information about Author(s)
Mara Paterson is a senior chemistry major and has been involved in undergraduate research since January of 2017. Her interests in both organic and inorganic chemistry led her to begin working on this project, which ultimately became the focus of her honors work in August of 2018. Next semester, she will be attending graduate school to earn her PhD in organic chemistry, followed by a career as a professor.