Level of Education of Students Involved

Undergraduate

Faculty Sponsor

Reva Johnson

College

College of Engineering (COE)

Discipline(s)

Biomedical Engineering

Presentation Type

Poster Presentation

Symposium Date

Spring 4-30-2026

Abstract

Dental caries is one of the most prevalent chronic diseases worldwide, and stannous fluoride (SnF2) is a compound known for its remineralizing and antimicrobial properties. Ferumoxytol, a superparamagnetic nanoparticle with enzyme-like activity, has been shown to enhance the antimicrobial activity of SnF2. This in vitro study evaluated the remineralization, antimicrobial, and dentin tubular occlusion effects of ferumoxytol-stabilized SnF2 (Fer-SnF2) at full and quarter concentrations compared to SnF2 alone and a negative control. It was hypothesized that Fer-SnF2 would enhance dentin surface hardness recovery following an acid challenge and promote dentin tubule occlusion more effectively than standard SnF2. Twenty human dentin specimens were divided into four groups and subjected to demineralization, biofilm formation, and cyclic treatments. Surface microhardness (SMH), biofilm viability (log CFU/mL), and scanning electron microscopy (SEM) imaging were analyzed. Full concentration Fer-SnF2 showed a statistically significant increase in SMH compared to SnF2 alone (p=0.05), quarter concentration (p=0.03) and control (p=0.02). While both nanozyme treated groups demonstrated greater biofilm reduction than SnF2, the differences were not statistically significant. SEM imaging revealed dentin tubule occlusion in Fer-SnF2 samples. These results indicate that ferumoxytol enhances the remineralization and dentin tubule occlusion effects of SnF2, supporting its potential in preventive dentistry. Further studies are needed to quantify occlusion and assess long term outcomes.

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