Arts and Sciences
Pterin based compounds have shown some promise as potential anti-fungal compounds; however, the low solubility of them in most organic solvents make the synthesis of these compounds tedious and difficult. Work is underway to do some of the steps of the synthesis in a different order to avoid the solubility issues. The goal is to be able to synthesize the final furan intermediate before adding the very insoluble pterin group in the final step to bypass any solubility issues that were encountered in synthesizing this molecule. First, the chlorinated furan intermediate underwent a reaction with sodium azide to convert the chlorine group on the furan into an azide group. Currently, work is being done on the second step, a DBU amidation to convert an ester to an amide group with a BOC protected amine.
Kohlmeyer, Kyle J. and Toman, Charlie, "New Ways of Synthesizing Potential Pterin Anti-Fungal Drugs" (2021). Summer Interdisciplinary Research Symposium. 94.