Design and Synthesis of a Potential Anti-fungal Agent
Arts and Sciences
Fungal infections are a serious concern, as they impact many people and have high mortality rates for those who are immunocompromised. As a result of drug-resistant microbes, there is always a need for new drugs to combat these infections, without causing side effects in humans. Taking advantage of differences in the Methionine Synthase (MetSyn) enzyme, found in both humans and fungi, our desired antifungal drug class binds exclusively to the fungal enzyme, inhibiting growth while leaving the host unaffected. We are synthesizing, and improving the synthesis of, a variety of inhibitors using pterin and deazaguanine-based molecules as the folate mimic, an essential substrate for MetSyn function. We have been testing these molecules' activity in a microbial growth assay.
Wolf, Hallie and Pruet, Jeffrey, "Design and Synthesis of a Potential Anti-fungal Agent" (2023). Summer Interdisciplinary Research Symposium. 153.