Faculty Sponsor

Jana Stedman

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Physician Assistant

ORCID Identifier(s)


Presentation Type

Poster Presentation

Symposium Date

Summer 7-26-2023


Objective: Tardive dyskinesia is a movement disorder commonly caused by antipsychotic medications. This review aims to determine the effectiveness of VMAT-2 inhibitors for the treatment of antipsychotic-induced tardive dyskinesia evaluated by reduction in AIMS scores.

Methods: Twelve articles were used including six systematic trials, one meta-analysis, two placebo-controlled trials, one prospective study, one cross-sectional study, and one assessment manual using the Google Scholar, Pubmed, and Summon. The primary endpoint included relative reduction in AIMS scores in each cohort.

Results: Deutetrabenazine and valbenazine show statistically significant reduction on AIMS scores compared to placebo. Vitamin E as treatment has been researched but little data is available on the effectiveness of treatment.

Conclusions: Through the research, VMAT-2 inhibitors, specifically deutetrabenazine and valbenazine, do result in efficacious treatment of tardive dyskinesia which is seen through statistically significant decrease in AIMS scores.

Keywords: deutetrabenazine, valbenazine, tardive dyskinesia, antipsychotic, VMAT-2 inhibitor, AIMS scores, vitamin E

Biographical Information about Author(s)

Peyton Westcott has completed 7 core clinical rotations and 2 elective rotations in the PICU and a second rotation in OBGYN in the Valparaiso Physician Assistant Program. Her favorite rotation was Internal Medicine because she was working with a hospitalist group and though this rotation, she found a love for hospitalist medicine. Peyton’s favorite memory this year getting to work with a wide variety of preceptors and form unique relationships with several of her preceptors