Development of EDTA Crosslinked Beta-Cyclodextrin for Use in Drug-Eluting Cardiovascular Stents

Primary Submission Contact

Grace Burkhart

Faculty Sponsor

Dr. Jennifer Holt

Faculty Sponsor Email Address



Arts and Sciences



Document Type

Poster Presentation


Fall 10-25-2019


Drug-eluting stents (DES) reduce the occurrence of in-stent restenosis in patients who have a stent placed in cardiac arteries. However, current DES do not have a long enough window of drug release to prevent late in-stent restenosis. Beta-cyclodextrin (BCD), a polymer which is capable of drug elution, has a high biocompatibility, and is able to be refilled with drug, is polymerized using Ethylenediaminetetraacetic acid (EDTA). The EDTA-BCD polymer particles have shown good attachment on Cobalt Chromium cardiovascular stents through imaging with SEM and analysis with EDS. Drug release studies done on the particles have shown extended drug release, showing that EDTA-BCD polymers have the capability of being a refillable and biocompatible coating for cardiovascular stents that can reduce the occurrence of late in-stent restenosis.

Biographical Information about Author(s)

Grace Burkhart is a senior at Valparaiso University, and spent the summer researching with Kathleen Young and Nathan Mu in Professor Horst von Recum's lab at Case Western Reserve University.

Additional Presentation Information

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