Commensal Bacteria May Promote Survival in Septic Mice

Primary Submission Contact

Kassidy Grumbles

Faculty Sponsor

Dr. Wischmeyer/Dr. Goyne

Faculty Sponsor Email Address

paul.wischmeyer@duke.edu/ thomas.goyne@valpo.edu


Arts and Sciences



Document Type

Poster Presentation


Fall 10-26-2018


The microbiome is made up of a vast array of bacteria and microorganisms that help to maintain our bodily functions. In critical care, the microbiome is now being looked at as a potential solution due to the dramatic shift in it seen in critical care patients. If we can identify beneficial bacteria to reduce the effects of sepsis experienced in critical care, it is possible that we can reduce the rate of sepsis. Identifying beneficial bacteria is not the only goal; we would like to understand how beneficial bacteria inhibits the growth of harmful bacteria typically found in sepsis. We identified Lactobacilli as a beneficial bacteria already found in the human microbiome as well as have used it in previous studies. The Lactobacilli will be used in established critical care mouse models to determine if the metabolites and/or factors help to reduce the effects of sepsis. The Lactobacilli species were also tested in liquid culture to see if the metabolites and/or factors inhibit the growth of Staphylococcus aureus. Identifying a metabolite/factor that inhibits bacterial growth could be used as a potential critical care therapeutic and improve ICU outcomes.

Additional Presentation Information

Wall Poster

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