Commensal Bacteria May Promote Survival in Septic Mice
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Dr. Wischmeyer/Dr. Goyne
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Arts and Sciences
The microbiome is made up of a vast array of bacteria and microorganisms that help to maintain our bodily functions. In critical care, the microbiome is now being looked at as a potential solution due to the dramatic shift in it seen in critical care patients. If we can identify beneficial bacteria to reduce the effects of sepsis experienced in critical care, it is possible that we can reduce the rate of sepsis. Identifying beneficial bacteria is not the only goal; we would like to understand how beneficial bacteria inhibits the growth of harmful bacteria typically found in sepsis. We identified Lactobacilli as a beneficial bacteria already found in the human microbiome as well as have used it in previous studies. The Lactobacilli will be used in established critical care mouse models to determine if the metabolites and/or factors help to reduce the effects of sepsis. The Lactobacilli species were also tested in liquid culture to see if the metabolites and/or factors inhibit the growth of Staphylococcus aureus. Identifying a metabolite/factor that inhibits bacterial growth could be used as a potential critical care therapeutic and improve ICU outcomes.
Grumbles, Kassidy; Davison, James Dr.; and Wischmeyer, Paul Dr., "Commensal Bacteria May Promote Survival in Septic Mice" (2018). Fall Interdisciplinary Research Symposium. 101.
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