Faculty Sponsor

Jeff Pruet

College

Arts and Sciences

Discipline(s)

Organic Chemistry, Biochemistry

ORCID Identifier(s)

Zach Bennett, https://orcid.org/0000-0001-5407-1523

Presentation Type

Poster Presentation

Symposium Date

Spring 4-1-2020

Abstract

Fungal infections are of continuous concern, especially with regard to immunocompromised patients. In an effort to develop new potential anti-fungal agents, we have begun synthesizing a library of potential inhibitors of the fungal Methionine Synthase (MetSyn) enzyme. Key differences between the B12-independant fungal MetSyn enzyme and the B12-dependant mammalian form can allow for an antifungal drug to be developed to exclusively bind the fungal enzyme and inhibit fungal growth while leaving the host (patient) unaffected. We are currently exploring the synthesis of various pterin and deazaguanine-based molecules as these mimic folate, an essential substrate for MetSyn function. We have begun testing these new molecules for activity in a fungal growth assay, as well as a fluorescent assay for monitoring MetSyn activity.

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