Faculty Sponsor

Dr. Kevin Jantzi


Arts and Sciences



Presentation Type

Poster Presentation

Symposium Date

Spring 5-3-2019


Pd(0)-catalyzed trimethylenemethane (TMM) cycloaddition reactions have been used extensively to generate disubstituted 5-membered rings with high levels of regioselectivity, chemoselectivity, and stereoselectivity. We aim to improve upon existing methodologies by introducing an epoxide into the TMM precursor, which should yield more highly functionalized products. A three step synthesis of a TMM precursor has been achieved in 20% overall yield. Efforts are underway to determine the reactivity of this precursor in Pd(0)-catalyzed cycloaddition reactions with substituted alkenes.

Biographical Information about Author(s)

Mara Paterson is a senior chemistry major and has been involved in undergraduate research since January of 2017. Her interests in both organic and inorganic chemistry led her to begin working on this project, which ultimately became the focus of her honors work in August of 2018. Next semester, she will be attending graduate school to earn her PhD in organic chemistry, followed by a career as a professor.