Title

Optimized Routes to 7-Carboxymethyl-Pterin: A Useful Building Block for Medicinal Chemists

Faculty Sponsor

Jeff Pruet

College

Arts and Sciences

Department/Program

Chemistry

Presentation Type

Poster Presentation

Symposium Date

Spring 5-3-2018

Abstract

Pterins are a class of nitrogen-heterocycle with wide application in the field of medicinal chemistry. The importance of pterin derivatives stems from discovery of numerous biologically relevant pterins, such as folate and bioterin. Due to this biological relevance, several pterin-based inhibitors have been developed for various biological targets. In this regard pterins can be viewed as a privileged scaffold, as the discovery of new pterin analogs gives rise to a vast array of potential drug candidates. 7-carboxymethyl-pterin (7-CMP) has previously been shown as a useful scaffold for the rapid generation of structurally diverse pterin amides. We are currently exploring multiple routes towards 7-CMP to assess the most efficient method of generating this useful scaffold. We intend to use 7-CMP as a building block in our search for selective inhibitors of fungal methionine synthase.

Biographical Information about Author(s)

Dr. Jeff Pruet received his PhD in organic chemistry from the University of Texas, working on the synthesis of small molecule inhibitors of Ricin Toxin A. He has over ten years of experience in the exploration of heterocyclic chemistry, and the use of various heterocycles for therapeutic applications. He has been a faculty member at Valparaiso University since the fall of 2017.

Zach Bennett and Kassidy Grumbles are both undergraduates in the chemistry department at Valparaiso University.

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