Arts and Sciences
Pterins are a class of nitrogen-heterocycle with wide application in the field of medicinal chemistry. The importance of pterin derivatives stems from discovery of numerous biologically relevant pterins, such as folate and bioterin. Due to this biological relevance, several pterin-based inhibitors have been developed for various biological targets. In this regard pterins can be viewed as a privileged scaffold, as the discovery of new pterin analogs gives rise to a vast array of potential drug candidates. 7-carboxymethyl-pterin (7-CMP) has previously been shown as a useful scaffold for the rapid generation of structurally diverse pterin amides. We are currently exploring multiple routes towards 7-CMP to assess the most efficient method of generating this useful scaffold. We intend to use 7-CMP as a building block in our search for selective inhibitors of fungal methionine synthase.
Pruet, Jeff; Grumbles, Kassidy; and Bennett, Zachary, "Optimized Routes to 7-Carboxymethyl-Pterin: A Useful Building Block for Medicinal Chemists" (2018). Symposium on Undergraduate Research and Creative Expression (SOURCE). 729.