Development of a Robust Organic Chemistry Lab
Arts and Sciences
Development of an Organic Chemistry Lab
The development of a more robust organic chemistry lab involving epoxide ring opening under acidic and basic conditions was accomplished through extensive studies using methanol as the major solvent and three different starting materials (propylene oxide, isobutylene oxide, and styrene oxide). The reactions for each of the three different starting materials were performed on the same scale, completed after a 30 minute reflux period, and the products were analyzed with NMR and GC-MS. The results obtained from each of the reactions are consistent with expected values (acid catalyzed favored more substituted carbon addition while base catalyzed favored addition to the less substituted carbon) which can be inferred through knowledge of the fundamental concepts within organic chemistry.
Ratic, Nikola, "Development of a Robust Organic Chemistry Lab" (2014). Symposium on Undergraduate Research and Creative Expression (SOURCE). 388.