Presentation Type

Oral Presentation

Symposium Date

Spring 4-24-2013


The equilibrium of a guest molecule binding to a host occurs through weak molecular interactions instead of through the formation of chemical bonds. A cyclodextrin (CD) is used as the host molecule due to its basket-like shape which is beneficial to complex formation with the guest molecule, Brooker’s merocyanine (BM), which fits well within beta-CD. BM is a highly conjugated dye that can exhibit a charge, allowing for a variety of the weak molecular interactions involved with complex formation, such as hydrogen bonds, to be studied. This project focuses on the effect of different modifications to the CD on the binding constant of BM with a CD host. The binding constant can be determined using the Benesi-Hildebrand equation to process data collected using UV-Vis and fluorescence spectroscopy. The determination of binding constants for multiple different CD modifications, including beta-CD, hydroxypropyl-beta-CD, and triacetyl-beta-CD, will allow for a comparison of how these modifications affect the degree of binding as well as whether or not hydrogen bonding is an important factor in the binding of this host-guest system. A better understanding of the factors that affect binding in host-guest systems will allow for better predictions of their behavior under different conditions.

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