The Synthesis of Potential Anti-fungal Compounds
Level of Education of Students Involved
Arts and Sciences
Fungal infections are very common throughout the world, but there is a lack of effective anti-fungal compounds. New anti-fungal compounds (e.g., D) are being developed to inhibit Methionine Synthase; an enzyme responsible for making the essential amino acid methionine. Previous investigations have shown that compounds containing the Pterin group demonstrated potential anti-fungal activity; however, it is challenging to synthesize these compounds because of insolubility and competition issues. To combat these issues, work is being conducted on adding the Pterin group at the end of the synthesis thereby bypassing the insolubility and competition issues. So far, the Boc Amine group (B) has been added to the starting material (A). Work is being done now in scaling up the (AB) reaction and eventually add the Pterin group (C).
Walda, Evan and Jantzi, Kevin, "The Synthesis of Potential Anti-fungal Compounds" (2023). Symposium on Undergraduate Research and Creative Expression (SOURCE). 1165.
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