Title

Interaction of Metallic Clusters With Biologically Active Curcumin Molecules

Authors

Sanjeev K. Gupta
Haiying He, Valparaiso University
Chunhui Liu

Document Type

Article

Publication Date

1-1-2015

Journal Title

Chemical Physics Letters

Volume

636

Abstract

Abstract We have investigated the interaction of subnano metallic Gd and Au clusters with curcumin, an important biomolecule having pharmacological activity. Gd clusters show different site preference to curcumin and much stronger interaction strength, in support of the successful synthesis of highly stable curcumin-coated Gd nanoparticles as reported recently. It can be attributed to significant charge transfer from the Gd cluster to curcumin together with a relatively strong hybridization of the Gd df-orbitals with curcumin p-orbitals. These results suggest that Gd nanoparticles can effectively be used as delivery carriers for curcumin at the cellular level for therapy and medical imaging applications.

Recommended Citation

Gupta, Sanjeev K.; He, Haiying; and Liu, Chunhui, "Interaction of Metallic Clusters With Biologically Active Curcumin Molecules" (2015). Physics and Astronomy Faculty Publications. 121.
https://scholar.valpo.edu/phys_astro_fac_pub/121