Background. Pancreatic encephalopathy is a rare complication of severe acute pancreatitis, with high mortality, being difficult to diagnose and treat, thus requiring continuous research regarding its management.

Materials and Methods. Of 20 patients diagnosed with severe acute pancreatitis on admission at Department of Emergency and Admission (DEA), from January 1st 2010 to March 31st 2014, 5 cases complicated by pancreatic encephalopathy were analyzed using a descriptive observational, retrospective, single-centre study.

Results. The study shows different types of diagnostic algorithm and therapeutical approaches, in correlation with morbidity and mortality rates.

Conclusions. Our study highlighted the fact that speed is critical, early management being the key to outcome.

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