Synthesis and characterization of a 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-containing amino acid
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Unnatural fluorescent amino acids are important tools that allow biochemists to visualize proteins in living cells. The addition of an unnatural fluorescent amino acid makes any normally transparent proteins to glow in the dark. The goal of this research is to synthesize the unnatural fluorescent amino acids shown in the reaction equation below (protected amino acid: R = t-Boc; deprotected amino acid: R = H). We have LC-MS data supporting the formation of the deprotected amino acid (m/z = 269.13 (observed); m/z = 269.08 (predicted)).
Winkle, Dana Ann, "Synthesis and characterization of a 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-containing amino acid" (2016). Fall Interdisciplinary Research Symposium. Paper 9.
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