Primary Submission Contact

Jeff Pruet

Faculty Sponsor

Jeff Pruet

Faculty Sponsor Email Address

jeffrey.pruet@valpo.edu

College

Arts and Sciences

Department/Program

Chemistry

Document Type

Poster Presentation

Date

Fall 10-27-2017

Abstract

Methionine Synthase (MetSyn) is an essential enzyme for all organisms. Taking advantage of key differences between fungal MetSyn and mammalian MetSyn, an antifungal drug could be developed to exclusively inactivate the fungal cell while leaving the host (patient) unaffected. To develop an inhibitor of fungal MetSyn we have begun the synthesis on two molecules which mimic folate, a necessary compound for MetSyn to function.

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