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Dr. Jennifer Holt
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Arts and Sciences
Host-guest chemistry refers to the chemistry in which a host and a guest molecule come together to form an inclusion complex. These complexes are utilized in numerous fields, including pharmaceuticals, agriculture, and cosmetics. This study focuses on the kinetic and thermodynamic behavior of a guest molecule, Brooker's merocyanine, in β-cyclodextrin and its different derivatives (the hosts) at a fundamental level in an attempt to increase stability of the complexes. UV-Vis spectroscopy was used to study the kinetic stability of Brooker's merocyanine's unique, energy dependent isomerization pathway inside the cavity of the host molecule in solution. It was found that when the guest molecule is in acidic conditions, it will isomerize more quickly from the trans form to the cis form when inside the cavity compared to solution; also, the cyclodextrin derivatives showed minimal differences on the rate of isomerization. Under basic conditions, it is well known that the guest molecule will isomerize from the cis form to the trans form with a required input of energy in solution; however, we found that no additional UV energy is needed for isomerization in complex. Fluorescence spectroscopy was used to study the thermodynamic stability of this system to determine how well the Brooker's merocyanine interacts with different cyclodextrin derivatives.
Sayger, Charles M., "Spectroscopic Analysis of the Kinetics of Host-Guest Chemistry Abstract" (2015). Fall Interdisciplinary Research Symposium. 52.
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