Title

Ligand Binding Studies of Metalloporphyrins

Faculty Sponsor

Steven Engerer

College

Arts and Sciences

Department/Program

Chemistry

Document Type

Poster Presentation

Symposium Date

Summer 7-31-2014

Abstract

Porphyrin molecules are found in numerous proteins important in biological processes. The porphyrin used in this project, tetraphenylprophryin (TPP), is a model compound used to study the iron-containing porphyrin found in hemoglobin responsible for transporting oxygen in the blood. In this work, TPP was synthesized and several metals including Zinc, Iron, and Manganese were reacted with TPP to form metalloporphyrins. UV-Visible and NMR spectroscopy was used to confirm the correct identity of products. The addition of amine ligands to these metalloporphyrins was then performed to study how metal identity affects ligand binding. To date, trials using pyrrolidine and piperidine have been performed successfully with more amines to be attempted later.

Biographical Information about Author(s)

Emily Sallman is a senior biochemistry major from Farmington Hills, MI. She plans to attend medical school in the fall of 2015 after she graduates in December.

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