Ligand Binding Studies of Metalloporphyrins
Faculty Sponsor
Steven Engerer
College
Arts and Sciences
Discipline(s)
Chemistry
Presentation Type
Poster Presentation
Symposium Date
Summer 7-31-2014
Abstract
Porphyrin molecules are found in numerous proteins important in biological processes. The porphyrin used in this project, tetraphenylprophryin (TPP), is a model compound used to study the iron-containing porphyrin found in hemoglobin responsible for transporting oxygen in the blood. In this work, TPP was synthesized and several metals including Zinc, Iron, and Manganese were reacted with TPP to form metalloporphyrins. UV-Visible and NMR spectroscopy was used to confirm the correct identity of products. The addition of amine ligands to these metalloporphyrins was then performed to study how metal identity affects ligand binding. To date, trials using pyrrolidine and piperidine have been performed successfully with more amines to be attempted later.
Recommended Citation
Sallman, Emily, "Ligand Binding Studies of Metalloporphyrins" (2014). Symposium on Undergraduate Research and Creative Expression (SOURCE). 386.
https://scholar.valpo.edu/cus/386
Biographical Information about Author(s)
Emily Sallman is a senior biochemistry major from Farmington Hills, MI. She plans to attend medical school in the fall of 2015 after she graduates in December.