Preparation of an Epoxide Precursor for Palladium-Catalyzed Trimethylenemethane Cycloaddition

Authors

Chase Freeland, Valparaiso UniversityFollow
William Prusinski, Valparaiso University

Faculty Sponsor

Kevin Jantzi

College

Arts and Sciences

Discipline(s)

Chemistry

Presentation Type

Poster Presentation

Symposium Date

5-3-2014

Abstract

In order to produce a highly functionalized five-membered ring useful for further synthetic processes via palladium catalysis, a series of precursors need to be synthesized in order to form the epoxide used in cyclic formation. First, a trimethylsilane alcohol is synthesized from beta-methallyl alcohol. The alcohol will then be subjected to Swern oxidation conditions, forming a TMS aldehyde. The aldehyde prepared will then undergo epoxidation, forming the desired precursor for Palladium catalyzed cycloaddition. These reactions occur in good conversion, and a good amount of epoxide is being amassed for use in the palladium-catalyzed cycloaddition research.

Biographical Information about Author(s)

No information provided.

Recommended Citation

Freeland, Chase and Prusinski, William, "Preparation of an Epoxide Precursor for Palladium-Catalyzed Trimethylenemethane Cycloaddition" (2014). Symposium on Undergraduate Research and Creative Expression (SOURCE). 328.
https://scholar.valpo.edu/cus/328